Invention Grant
- Patent Title: High affinity Melan-A T cell receptors
- Patent Title (中): 高亲和力的Melan-A T细胞受体
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Application No.: US11915766Application Date: 2006-05-31
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Publication No.: US08217144B2Publication Date: 2012-07-10
- Inventor: Bent Karsten Jakobsen , Nathaniel Ross Liddy
- Applicant: Bent Karsten Jakobsen , Nathaniel Ross Liddy
- Applicant Address: GB Oxon
- Assignee: Immunocore Ltd.
- Current Assignee: Immunocore Ltd.
- Current Assignee Address: GB Oxon
- Agency: Vedder Price P.C.
- Agent Thomas J. Kowalski; Smitha B. Uthaman
- Priority: GB0511124.0 20050601
- International Application: PCT/GB2006/001980 WO 20060531
- International Announcement: WO2006/129085 WO 20061207
- Main IPC: C07K1/00
- IPC: C07K1/00 ; C07K14/00 ; C07K17/00
Abstract:
The present invention provides TCRs having an affinity (KD) of less than or equal to 3 μM, and/or an off-rate (koff) of 1×10−3 S−1 or slower, for the AAGIGILTV-HLA-A*0201 complex. Such TCRs are useful, either alone or associated with a therapeutic agent, for targeting cancer cells presenting that complex.
Public/Granted literature
- US20080292549A1 High Affinity Melan-A T Cell Receptors Public/Granted day:2008-11-27
Information query
