Invention Grant
US08217178B2 [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[7-flouro-1-(2-methoxy-ethyl)-4-trifluorom as an inhibitor of mast cell tryptase
有权
[4-(5-氨基甲基-2-氟 - 苯基) - 哌啶-1-基] - [7-氟-1-(2-甲氧基 - 乙基)-4-三氟甲磺隆作为肥大细胞类胰蛋白酶抑制剂
- Patent Title: [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[7-flouro-1-(2-methoxy-ethyl)-4-trifluorom as an inhibitor of mast cell tryptase
- Patent Title (中): [4-(5-氨基甲基-2-氟 - 苯基) - 哌啶-1-基] - [7-氟-1-(2-甲氧基 - 乙基)-4-三氟甲磺隆作为肥大细胞类胰蛋白酶抑制剂
-
Application No.: US13028745Application Date: 2011-02-16
-
Publication No.: US08217178B2Publication Date: 2012-07-10
- Inventor: Yong Mi Choi-Sledeski , Nakyen Choy , Gregory Bernard Poli , John J. Shay, Jr. , Patrick Wai-Kwok Shum , Adam W. Sledeski
- Applicant: Yong Mi Choi-Sledeski , Nakyen Choy , Gregory Bernard Poli , John J. Shay, Jr. , Patrick Wai-Kwok Shum , Adam W. Sledeski
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agent Ronald G. Ort
- Main IPC: C07D401/00
- IPC: C07D401/00 ; A61K31/445
![[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[7-flouro-1-(2-methoxy-ethyl)-4-trifluorom as an inhibitor of mast cell tryptase](/abs-image/US/2012/07/10/US08217178B2/abs.jpg.150x150.jpg)
Abstract:
The present invention is directed to an indole benzylamine compound of formula I: useful as an inhibitor of tryptase. In addition, the present invention is directed to the use of the compound for treating a patient suffering from, or subject to, a physiological condition in need of amelioration by inhibition of tryptase, comprising administering to the patient of a therapeutically effective amount of the compound, and to a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula I, and a pharmaceutically acceptable carrier.
Public/Granted literature
Information query