Transmission with multiple antennas in a wireless network is performed by transmitting a plurality of reference sequences (RS) from a UE. A first RS s1[k] is produced using a first cyclic shift and a base sequence s0[k], wherein k={1, 2 . . . K} is an element index. A second RS s2[k] is produced using a second cyclic shift and s0[k]. A first symbol sequence x1[k] is produced using at least s1[k] and s2[k], for at least one k. A second symbol sequence x2[k] is produced using at least s1[k] and s2[k], for at least one k. x1[k] is transmitted using a first transmit antenna and x2[k] is transmitted using a second transmit antenna.