Aspects of a method and system for compensating for estimated distortion in a transmitter by utilizing a digital predistortion scheme with a quadrature feedback mixer configuration are presented. Aspects of the system may include an RF transmitter that enables generation of an RF output signal in response to one or more generated input signals. One or more feedback signals may be generated by performing frequency downconversion on the RF output signal within a corresponding one or more feedback mixer circuits. The generated one or more feedback signals may be inserted at a corresponding one or more insertion points in an RF receiver. Each insertion point may be between a receiver mixer circuit and corresponding circuits that generate a baseband signal based on the corresponding one of the feedback signals.