Invention Grant
US08219323B2 System and method for quantifying the sequence specificity of nucleotide binding factors
有权
用于量化核苷酸结合因子的序列特异性的系统和方法
- Patent Title: System and method for quantifying the sequence specificity of nucleotide binding factors
- Patent Title (中): 用于量化核苷酸结合因子的序列特异性的系统和方法
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Application No.: US11803777Application Date: 2007-05-16
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Publication No.: US08219323B2Publication Date: 2012-07-10
- Inventor: Harmen J. Bussemaker , Barrett C. Foat , Ronald G. Tepper
- Applicant: Harmen J. Bussemaker , Barrett C. Foat , Ronald G. Tepper
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agency: Baker Botts, L.L.P.
- Main IPC: G01N33/48
- IPC: G01N33/48 ; C12Q1/68 ; G06F7/60 ; G06G7/58
Abstract:
Systems and methods for determining free energy parameters for predicting binding affinities of nucleotide sequences are provided. The disclosed subject matter obtains phenotypic measurements for nucleotide sequences (for example a DNA sequence or RNA sequence), links the phenotypic measurements to the nucleotide sequences to obtain linked pairs of phenotypic measurements and nucleotide sequences, estimates a relationship between the phenotypic measurements and the nucleotide sequences using the linked pairs, and obtains sequence specific affinity parameters from the estimated relationship.
Public/Granted literature
- US20080102460A1 System and method for quantifying the sequence specificity of nucleotide binding factors Public/Granted day:2008-05-01
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