A frame compensation method is provided. The method includes: obtaining a length of a lost frame and a length of a correct frame; determining that the length of the correct frame is integral power of 2 times of the length of the lost frame, and then obtaining a data sequence with the same length as the length of the lost frame according to the correct frame; and compensating the lost frame according to the data sequence to obtain a compensated data frame. A frame compensation system is also provided. Lost frames in various formats are compensated according to correct frames in various formats, so that the limitation of the related art that a lost frame in a single format can be merely compensated according to a correct frame in a single format is eliminated, and the effect of the compensated data frames is better than that of filling comfort noises.