A hinged clamp provides quick connection and disconnection of sections of fluid tubing. Some embodiments include a spring-loaded catch mechanism that enables the clamp to be loosely latched, and a winding mechanism that can retract the catch to a securely latched condition. Other embodiments provide a hinged shaft that pivots about an end of the upper clamp ring. A middle section of the shaft can be inserted into a slotted opening in the lower clamp ring, and the winding mechanism can move an engagement surface against the lower clamp ring to securely latch the clamp. An adjustment mechanism is included in these embodiments which can adjust the amount of winding required to engage the clamp. In various embodiments, less than one turn or less than one-half turn is required to engage/disengage the clamp. The clamp can be openable only just enough for insertion of flanged ends of the tubing sections.