A luer activated device includes an inlet adapted to receive a male luer, an outlet associable with a fluid flow system, and a fluid flow path therebetween. The flow path is defined by an elastomeric flow controller extending between the inlet and outlet and maintained in a tensioned state. When a male luer is inserted into the inlet, some of the tension in the flow controller is relieved, allowing the flow path to deform and change in volume. The flow path is adapted such that the change in volume results in no net fluid displacement or minimal positive fluid displacement when the male luer is inserted into the inlet. Other aspects include tensioned flow controllers having a plurality of sealing layers for the inlet and methods of manufacturing valves having a tensioned fluid flow controller.