Invention Grant
- Patent Title: Enhancement of bactericidal activity of neisseria antigens with oligonucleotides containing CG motifs
- Patent Title (中): 用含有CG基序的寡核苷酸增强奈瑟菌抗原的杀菌活性
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Application No.: US09914454Application Date: 2000-02-09
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Publication No.: US08221761B1Publication Date: 2012-07-17
- Inventor: Guido Grandi , Rino Rappuoli , Marzia M. Giuliani , Mariagrazia Pizza
- Applicant: Guido Grandi , Rino Rappuoli , Marzia M. Giuliani , Mariagrazia Pizza
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Amy Hessler; Otis Littlefield
- International Application: PCT/IB00/00176 WO 20000209
- International Announcement: WO00/50075 WO 20000831
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/38 ; A61K45/00 ; A61K47/00 ; A61K39/02 ; A61K39/095
Abstract:
Immunogenic compositions (e.g. vaccines) comprising: (a) an immunostimulating amount of a Neisseria antigen (preferably N. meningitidis serogroup B); and (b) an immunostimulating amount of an adjuvant composition comprising an oligonucleotide comprising at least one CG motif. Component (b) may further comprise a second adjuvant. Component (a) may be selected from a variety of antigens. Adjuvant compositions comprising an oligonucleotide having at least one CG motif, and complete Freund's adjuvant (CFA) are also provided.
Information query
