The present invention describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating skin irritation, inflammation, and/or the signs of visible or subjective discomfort, wherein the compositions include natural plant constituents that inhibit at least one cytokine. The plant extracts are preferably derived from Populus nigra, Rhinacanthus nasutus, Sapindus rarak, and Thumbergia laurifolia, and any combinations thereof. The compositions are preferably applied to the skin, or are delivered by directed means, to a site in need thereof.