Invention Grant
US08221768B2 Chimeric flavivirus immunogens comprising the Japanese encephalitis virus (JEV) prM signal sequence
有权
包含日本脑炎病毒（JEV）prM信号序列的嵌合黄病毒免疫原
- Patent Title: Chimeric flavivirus immunogens comprising the Japanese encephalitis virus (JEV) prM signal sequence
- Patent Title (中): 包含日本脑炎病毒（JEV）prM信号序列的嵌合黄病毒免疫原
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Application No.: US12580080Application Date: 2009-10-15
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Publication No.: US08221768B2Publication Date: 2012-07-17
- Inventor: Gwong-Jen J. Chang
- Applicant: Gwong-Jen J. Chang
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
- Current Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP
- Main IPC: A61K39/12
- IPC: A61K39/12 ; A61K39/00
Abstract:
The present invention encompasses isolated nucleic acids containing transcriptional units which encode a signal sequence of one flavivirus and an immunogenic flavivirus antigen of a second flavivirus or of a chimeric immunogenic flavivirus antigen comprising sequence from more than one flavivirus. The invention further encompasses a nucleic acid and protein vaccine and the use of the vaccine to immunize a subject against flavivirus infection. The invention also provides antigens encoded by nucleic acids of the invention, antibodies elicited in response to the antigens and use of the antigens and/or antibodies in detecting flavivirus or diagnosing flavivirus infection.
Public/Granted literature
- US20100040643A1 FLAVIVIRUS IMMUNOGENS AND METHODS OF USE Public/Granted day:2010-02-18
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