Invention Grant
US08221992B2 Assays for determining compounds which modulate TRAM phosphorylation
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测定调节TRAM磷酸化的化合物的测定
- Patent Title: Assays for determining compounds which modulate TRAM phosphorylation
- Patent Title (中): 测定调节TRAM磷酸化的化合物的测定
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Application No.: US11910518Application Date: 2006-04-03
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Publication No.: US08221992B2Publication Date: 2012-07-17
- Inventor: Luke Anthony O'Neill , Anne McGettrick
- Applicant: Luke Anthony O'Neill , Anne McGettrick
- Applicant Address: IE Dublin
- Assignee: Opsona Therapeutics Limited
- Current Assignee: Opsona Therapeutics Limited
- Current Assignee Address: IE Dublin
- Agency: Lando & Anastasi, LLP
- Priority: GB0506768.1 20050402; GB0521325.1 20051020
- International Application: PCT/IE2006/000023 WO 20060403
- International Announcement: WO2006/106492 WO 20061012
- Main IPC: G01N33/567
- IPC: G01N33/567
Abstract:
Disclosed are assays for the determination and quantification of the phosphorylation of TRAM (Trif-related adaptor molecule). TRAM is rapidly phosphorylated upon LPS stimulation by protein kinase C epsilon (PKCε) and that this phosphorylation is vital for TRAM to function normally. Assays suitable for detecting the state of phosphorylation of TRAM have utility in identifying compounds which have activity in modulating TRAM. Further disclosed are compounds which have utility in modulating the phosphorylation of TRAM to modulate signalling mediating by the Toll Like Receptor 4 (TLR4) receptor.
Public/Granted literature
- US20090123482A1 ASSAYS FOR DETERMINING COMPOUNDS WHICH MODULATE TRAM PHOSPHORYLATION Public/Granted day:2009-05-14
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