Invention Grant
- Patent Title: Ketol-acid reductoisomerase using NADH
- Patent Title (中): 使用NADH的酮酸酸还原异构酶
-
Application No.: US13296969Application Date: 2011-11-15
-
Publication No.: US08222017B2Publication Date: 2012-07-17
- Inventor: Yougen Li , Der-Ing Liao , Mark J. Nelson , Daniel P. Okeefe , Jean-Francois Tomb
- Applicant: Yougen Li , Der-Ing Liao , Mark J. Nelson , Daniel P. Okeefe , Jean-Francois Tomb
- Applicant Address: US DE Wilmington
- Assignee: Butamax(TM) Advanced Biofuels LLC
- Current Assignee: Butamax(TM) Advanced Biofuels LLC
- Current Assignee Address: US DE Wilmington
- Agent Christine M. Lhulier
- Main IPC: C12N9/02
- IPC: C12N9/02 ; C12N15/00 ; C12P21/06 ; C12P21/04 ; C07H21/04
Abstract:
Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NADH are described.
Public/Granted literature
- US20120115197A1 Ketol-Acid Reductoisomerase Using NADH Public/Granted day:2012-05-10
Information query
