Invention Grant
US08222221B2 Modulation of gene expression through endogenous small RNA targeting of gene promoters
有权
通过基因启动子的内源性小RNA靶向调节基因表达
- Patent Title: Modulation of gene expression through endogenous small RNA targeting of gene promoters
- Patent Title (中): 通过基因启动子的内源性小RNA靶向调节基因表达
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Application No.: US12455588Application Date: 2009-06-03
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Publication No.: US08222221B2Publication Date: 2012-07-17
- Inventor: David R. Corey , Scott T. Younger
- Applicant: David R. Corey , Scott T. Younger
- Applicant Address: US TX Austin
- Assignee: The Board of Regents of the University of Texas System
- Current Assignee: The Board of Regents of the University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Fulbright & Jaworski
- Main IPC: C12N15/11
- IPC: C12N15/11
Abstract:
Gene expression can be selectively regulated by endogenous miRNAs that target promoters of genes. Altering of the activity of these promoter-targeting miRNAs with single-stranded complementary oligonucleotides that bind the miRNA causes modulation of expression of the target gene. Endogenous miRNAs that modulate expression of target genes can be identified by (a) evaluating an endogenous miRNA for complementarity to a target gene promoter; and (b) determining that the complementary miRNA modulates expression of the target gene.
Public/Granted literature
- US20090326051A1 Modulation of gene expression through endogenous small RNA targeting of gene promoters Public/Granted day:2009-12-31
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