Invention Grant
- Patent Title: Derivatives of partially desulphated glycosaminoglycans endowed with antiangiogenic activity and devoid of anticoagulating effect
- Patent Title (中): 部分脱硫糖胺聚糖衍生物具有抗血管生成活性，无抗凝作用
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Application No.: US12851166Application Date: 2010-08-05
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Publication No.: US08222231B2Publication Date: 2012-07-17
- Inventor: Benito Casu , Giangiacomo Torri , Anna Maria Naggi , Giuseppe Giannini , Claudio Pisano , Sergio Penco
- Applicant: Benito Casu , Giangiacomo Torri , Anna Maria Naggi , Giuseppe Giannini , Claudio Pisano , Sergio Penco
- Applicant Address: IT Rome
- Assignee: Sigma-Tau Industrie Farmaceutiche Riunite SpA
- Current Assignee: Sigma-Tau Industrie Farmaceutiche Riunite SpA
- Current Assignee Address: IT Rome
- Agency: Lucas & Mercanti, LLP
- Priority: ITRM00A0041 20000125
- Main IPC: A61K31/727
- IPC: A61K31/727 ; A61K31/715 ; A61P39/00
Abstract:
Partially desulfated glycosaminoglycan derivatives are described, particularly heparin, and more particularly formula (I) compounds where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives exhibit antiangiogenic activity and are devoid of anticoagulant activity.
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