Invention Grant
- Patent Title: Substituted isoxazoles
- Patent Title (中): 取代的异恶唑
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Application No.: US12748524Application Date: 2010-03-29
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Publication No.: US08222246B2Publication Date: 2012-07-17
- Inventor: Bernd Buettelmann , Stephen Deems Gabriel , Steven Paul Hanlon , Roland Jakob-Roetne , Matthew C. Lucas , Paul Spurr , Andrew Thomas , Pius Waldmeier
- Applicant: Bernd Buettelmann , Stephen Deems Gabriel , Steven Paul Hanlon , Roland Jakob-Roetne , Matthew C. Lucas , Paul Spurr , Andrew Thomas , Pius Waldmeier
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- Priority: EP09157200 20090402
- Main IPC: C07D413/02
- IPC: C07D413/02 ; A61K31/44
Abstract:
The present invention is concerned with novel hydroxy-methyl isoxazole derivatives of formula I wherein R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of the present invention have affinity and selectivity for GABA A α5 receptor. Further the present invention is concerned with the manufacture of the active compounds of formula I, pharmaceutical compositions containing them and their use as pharmaceuticals.
Public/Granted literature
- US20100256127A1 SUBSTITUTED ISOXAZOLES Public/Granted day:2010-10-07
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