Invention Grant
US08222259B2 1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidin-3-one compounds for use as adenosine A2a receptor antagonists
有权
1,2,4-三唑并[4,3-c]嘧啶-3-酮和吡唑并[4,3-e] -1,2,4-三唑并[4,3-c]嘧啶-3-酮 用作腺苷A2a受体拮抗剂
![1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidin-3-one compounds for use as adenosine A2a receptor antagonists](/docs/US/2012-07-17/US08222259B2/abs.jpg.600x600.jpg)
- Patent Title: 1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidin-3-one compounds for use as adenosine A2a receptor antagonists
- Patent Title (中): 1,2,4-三唑并[4,3-c]嘧啶-3-酮和吡唑并[4,3-e] -1,2,4-三唑并[4,3-c]嘧啶-3-酮 用作腺苷A2a受体拮抗剂
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Application No.: US12920924Application Date: 2009-03-03
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Publication No.: US08222259B2Publication Date: 2012-07-17
- Inventor: Joel M. Harris , Bernard R. Neustadt , Jinsong Hao , Andrew W. Stamford
- Applicant: Joel M. Harris , Bernard R. Neustadt , Jinsong Hao , Andrew W. Stamford
- Applicant Address: US NJ Rahway
- Assignee: Schering Corporation
- Current Assignee: Schering Corporation
- Current Assignee Address: US NJ Rahway
- Agent H. Eric Fischer; Gerard M. Devlin
- International Application: PCT/US2009/035839 WO 20090303
- International Announcement: WO2009/111449 WO 20090911
- Main IPC: C07D487/12
- IPC: C07D487/12 ; C07D487/14 ; C07D487/04 ; A61K31/519
![1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidin-3-one compounds for use as adenosine A2a receptor antagonists](/abs-image/US/2012/07/17/US08222259B2/abs.jpg.150x150.jpg)
Abstract:
Compounds of the Formula I wherein R1 and R2 together with the carbon atoms to which they are bonded optionally form a further heteroaromatic ring of the formula (II) as well as pharmaceutically acceptable salts, solvates, esters and prodrugs thereof are adenosine A2a receptor antagonists and, therefore, are useful in the treatment of central nervous system diseases, in particular Parkinson's disease.
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