Invention Grant
US08222273B2 Polymorphic form of a [1,2,4]triazole[4,3-A] pyridine derivative inflammatory diseases 有权
[1,2,4]三唑[4,3-A]吡啶衍生物炎症性疾病的多形态

  • Patent Title: Polymorphic form of a [1,2,4]triazole[4,3-A] pyridine derivative inflammatory diseases
  • Patent Title (中): [1,2,4]三唑[4,3-A]吡啶衍生物炎症性疾病的多形态
  • Application No.: US12865889
    Application Date: 2009-01-28
  • Publication No.: US08222273B2
    Publication Date: 2012-07-17
  • Inventor: Kenneth John Butcher
  • Applicant: Kenneth John Butcher
  • Applicant Address: GB Sandwich, Kent
  • Assignee: Pfizer Limited
  • Current Assignee: Pfizer Limited
  • Current Assignee Address: GB Sandwich, Kent
  • Agent A. David Joran; Mary J. Hosley
  • International Application: PCT/IB2009/050351 WO 20090128
  • International Announcement: WO2009/098612 WO 20090813
  • Main IPC: A61K31/437
  • IPC: A61K31/437 C07D471/07
Polymorphic form of a [1,2,4]triazole[4,3-A] pyridine derivative inflammatory diseases
Abstract:
The present invention relates to a polymorphic form B of Λ/-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-N-{2-[(3-{2-[(2-hydroxyethyl)sulfanyl]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)sulfanyl]benzyl}urea (I) as de-fined herein. This polymorph is useful in the treatment of various conditions, particularly in the treatment of inflammatory conditions such as chronic obstructive pulmonary disease.
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