Invention Grant
US08222286B2 Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
有权
取代的氨基甲酰甲基氨基乙酸衍生物作为新的NEP抑制剂
- Patent Title: Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
- Patent Title (中): 取代的氨基甲酰甲基氨基乙酸衍生物作为新的NEP抑制剂
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Application No.: US12947029Application Date: 2010-11-16
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Publication No.: US08222286B2Publication Date: 2012-07-17
- Inventor: Yuki Iwaki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi
- Applicant: Yuki Iwaki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Sophie Binet Cross
- Main IPC: A61K31/13
- IPC: A61K31/13 ; A61K31/41 ; A61K31/185 ; C07C61/00 ; C07C259/04 ; C07D257/04
Abstract:
The present invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R6, A1, A2, X1, s and m are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Public/Granted literature
- US20110124695A1 Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors Public/Granted day:2011-05-26
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