Invention Grant
- Patent Title: Bifunctional histone deacetylase inhibitors
- Patent Title (中): 双功能组蛋白脱乙酰酶抑制剂
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Application No.: US12279440Application Date: 2007-02-14
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Publication No.: US08222423B2Publication Date: 2012-07-17
- Inventor: James Elliot Bradner , Ralph Mazitschek , Tang Weiping , Stuart S. Schreiber
- Applicant: James Elliot Bradner , Ralph Mazitschek , Tang Weiping , Stuart S. Schreiber
- Applicant Address: US MA Boston US MA Cambridge US MD Chevy Chase
- Assignee: Dana-Farber Cancer Institute, Inc.,President and Fellows of Harvard College,Howard Hughes Medical Institute
- Current Assignee: Dana-Farber Cancer Institute, Inc.,President and Fellows of Harvard College,Howard Hughes Medical Institute
- Current Assignee Address: US MA Boston US MA Cambridge US MD Chevy Chase
- Agency: Wolf, Greenfield & Sacks, P.C.
- Agent C. Hunter Baker; Emilie Porter Huck
- International Application: PCT/US2007/062145 WO 20070214
- International Announcement: WO2008/091349 WO 20080731
- Main IPC: C07D249/00
- IPC: C07D249/00 ; C07C303/00
Abstract:
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel bifunctional, trifunctional, or multifunctional compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts and derivatives thereof. The present invention further provides methods for treating disorders regulated by histone deacetylase activity (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, hair loss, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.
Public/Granted literature
- US20090312363A1 BIFUNCTIONAL HISTONE DEACETYLASE INHIBITORS Public/Granted day:2009-12-17
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