An ultrasonic atomization circuit comprises a driving signal generating unit to generate an ultrasonic driving signal, a power unit to amplify and transmit the ultrasonic driving signal to a piezoelectric ceramic lamination, and a buffering unit connecting to the driving signal generating unit and the power unit to reduce the effect by the load of the power unit to the driving signal generating unit. The present invention is directed to provide an atomization device using the above ultrasonic atomization circuit. For the ultrasonic atomization circuit being disposed between the power unit and the driving signal generating unit, the ultrasonic atomization circuit can reduce the effect by the disperse circuits and reactance to the driving signal generating unit, meanwhile need less units and be easy to test.