A multipurpose wireless touchpad mouse includes a mouse body, a first button set and a second button set respectively mounted in the top and bottom sides of the mouse body, and a control module mounted in an accommodation chamber inside the mouse body and electrically connected with the first button set and the second button set for sensing the upside-up position or upside-down position of the mouse body by means of a direction sensor and for enabling a changeover switch controller thereof to switch between the first button set and the second button set subject to the upside-up or upside-down position of the mouse body sensed by the direction sensor so that the mouse body can be used with the first button set as a mouse, or used with the second button set as a remote controller, laser pointer, A/V controller, presentation remote controller, direction controller or game controller.