A frequency agile wireless response system and method of retrieving user response data from a plurality of users includes providing a base unit and a plurality of handheld response units, each communicating with the base unit over a wireless communication link using a frequency agile communication protocol. Base signals are sent with the base unit to the response units over the wireless communication link. Response signals are sent from the response units to the base unit over the wireless communication link. The base signals include a master transmission and at least occasionally include an extension transmission. The master transmission includes information establishing a time mark for the response units. The master transmission also includes information enabling the response units to receive any extension transmission associated with that base signal.