A method and a system for setting up header compression communication and a header compression policy function entity are disclosed herein. The method includes: a header compression enforcement function entity receives a header compression indication from a header compression policy function entity; and the header compression enforcement function entity negotiates header compression channel parameters with the other corresponding header compression enforcement function entity to set up header compression channel. A communication system and a header compression policy function entity are disclosed. The embodiments of the present disclosure overcome the failure of implementing the header compression communication in the prior art.