A therapy adherence system is provided. The system comprises at least one computer system, a database, and an application that, when executed on the at least one computer system, receives a message from a home-based patient device containing medication compliance information and physical condition information. The system also compares medication compliance information and physical condition information with a current treatment regimen and historical medication and physical condition information stored in the database. The system also calculates an updated regimen and health risk level based on at least current and historical medication compliance information and physical condition information. The system also notifies an at least one health care provider when health risk level exceeds a threshold. The system also receives response from the at least one health care provider, the response comprising adjustments to the updated regimen and a diagnosis and communicates the updated regimen.