A high-speed SerDes transmitter which may reduce power supply introduced data dependent jitter. Instead of trying to make the output voltage of a power supply of a pre-driver constant, the output voltage of the power supply is returned to its normal level periodically, e.g., after each bit time to follow the data rate of an input data stream. A complementary pre-driver may be used to create a complementary data stream which may be at the same data rate as the input data rate. The complementary data stream may have a transition when there is no transition between two consecutive bits in the input data stream, but have no transition when there is a transition in the input data stream. As a result, there is a transition at the power supply during each bit time, and the power supply may be drawn back to its normal level during each bit time. Consequently, the power supply variation is periodic at the beat of the input data rate, and the power supply may have the same impact on each data bit. Thus, each bit in the input data stream may see the same level of power supply, and data dependent jitter may be reduced or eliminated.