A computer-implemented method for detecting man-in-the-browser attacks may include identifying a transaction fingerprint associated with a web site. The method may also include tracking a user's input to the web site. The user's input may be received through a web browser. The method may further include intercepting an outgoing submission to the web site. The method may additionally include determining whether, in light of the transaction fingerprint, the user's input generated the outgoing submission. Various other methods, systems, and computer-readable media are also disclosed.