Invention Grant
US08226940B2 Enhancing the effect of therapeutic proteins on the central nervous system
失效
增强治疗性蛋白质对中枢神经系统的作用
- Patent Title: Enhancing the effect of therapeutic proteins on the central nervous system
- Patent Title (中): 增强治疗性蛋白质对中枢神经系统的作用
-
Application No.: US12714534Application Date: 2010-02-28
-
Publication No.: US08226940B2Publication Date: 2012-07-24
- Inventor: Shunji Tomatsu , Adriana Montano , Tatsuo Nishioka , Jeffrey H. Grubb , William S. Sly , Monica A. Gutierrez
- Applicant: Shunji Tomatsu , Adriana Montano , Tatsuo Nishioka , Jeffrey H. Grubb , William S. Sly , Monica A. Gutierrez , Amelia Ortigoza Rodriguez, legal representative
- Applicant Address: US MO Saint Louis
- Assignee: Saint Louis University
- Current Assignee: Saint Louis University
- Current Assignee Address: US MO Saint Louis
- Agency: The Law Office of Randolph Bretton
- Agent Randolph Bretton
- Main IPC: A61K38/47
- IPC: A61K38/47 ; A61K38/43 ; A61K38/00 ; C12N9/24 ; C12N9/14 ; C07H21/04 ; C07K1/00
Abstract:
The present invention provides a polypeptide therapeutic agent, useful in enzyme replacement therapy, with increased therapeutic benefits for the central nervous system. The invention provides a method of enhancing the effect of a polypeptide or protein on the central nervous system by the attachment of a short acidic amino acid sequence. Specifically the inventors disclose the attachment of a 4-15 acidic amino acid sequence to human β-glucuronidase by construction of a fusion protein. This molecule is useful in the treatment of type VII mucopolysaccharidosis when administered to a patient.
Public/Granted literature
- US20100158889A1 ENHANCING THE EFFECT OF THERAPEUTIC PROTEINS ON THE CENTRAL NERVOUS SYSTEM Public/Granted day:2010-06-24
Information query
IPC分类:
