Invention Grant
- Patent Title: Methods of purifying chondroitinase and stable formulations thereof
- Patent Title (中): 软骨素酶的纯化方法及其稳定配方
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Application No.: US11568831Application Date: 2005-05-18
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Publication No.: US08226941B2Publication Date: 2012-07-24
- Inventor: Anthony O. Caggiano , Elliott A. Gruskin , Yelena G. Sheptovitsky , Sarah Kasperbauer
- Applicant: Anthony O. Caggiano , Elliott A. Gruskin , Yelena G. Sheptovitsky , Sarah Kasperbauer
- Applicant Address: US NY Hawthorne
- Assignee: Acorda Therapeutics, Inc.
- Current Assignee: Acorda Therapeutics, Inc.
- Current Assignee Address: US NY Hawthorne
- Agency: Pepper Hamilton LLP
- International Application: PCT/US2005/017464 WO 20050518
- International Announcement: WO2005/112986 WO 20051201
- Main IPC: A61K38/46
- IPC: A61K38/46 ; A61K38/47 ; C12N9/24 ; C07H21/04
Abstract:
An aspect of the present invention relates to stable formulations of chondroitinase and to methods of purifying chondroitinase. The methods of purifying chondroitinase includes the steps of extracting the enzyme from a cell, separating the chondroitinase from the crude cell extract using cation-exchange chromatography, removing impurities through gel filtration chromatography, and removing endotoxin through an anion-exchange membrane to produce a purified chondroitinase.
Public/Granted literature
- US20080311642A1 Methods of Purifying Chondroitinase and Stable Formulations Thereof Public/Granted day:2008-12-18
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