Invention Grant
- Patent Title: Antibodies to notch receptors
- Patent Title (中): 抗缺陷受体的抗体
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Application No.: US12499627Application Date: 2009-07-08
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Publication No.: US08226943B2Publication Date: 2012-07-24
- Inventor: Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
- Applicant: Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
- Applicant Address: US CA Redwood City
- Assignee: OncoMed Pharmaceuticals, Inc.
- Current Assignee: OncoMed Pharmaceuticals, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Sterne, Kessler, Golstein & Fox P.L.L.C.
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; C07K14/705 ; C12N5/00
Abstract:
The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
Public/Granted literature
- US20100111958A1 Notch-Binding Agents and Antagonists and Methods of Use Thereof Public/Granted day:2010-05-06
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