Invention Grant
- Patent Title: Distinguishing assay
- Patent Title (中): 区分测定
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Application No.: US12745565Application Date: 2008-12-12
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Publication No.: US08227195B2Publication Date: 2012-07-24
- Inventor: Kay-Gunnar Stubenrauch , Markus Zadak
- Applicant: Kay-Gunnar Stubenrauch , Markus Zadak
- Applicant Address: US NJ Nutley
- Assignee: Hoffman-La Roche Inc.
- Current Assignee: Hoffman-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George W. Johnston; Dennis P. Tramaloni; Samuel H. Megerditchian
- Priority: EP07024353 20071215; EP08002450 20080211
- International Application: PCT/EP2008/010575 WO 20081212
- International Announcement: WO2009/077127 WO 20090625
- Main IPC: G01N33/53
- IPC: G01N33/53

Abstract:
The current invention comprises a method for determining of an antibody against a drug antibody in a sample using an immunoassay comprising a capture drug antibody and a tracer drug antibody, wherein the method comprises providing i) a capture drug antibody, which is the drug antibody conjugated to a solid phase, ii) a tracer drug antibody, which is the drug antibody conjugated to a detectable label, contacting the capture drug antibody separately with i) the sample, ii) the sample, to which the drug antibody in monomeric form has been added, iii) the sample, to which the drug antibody in oligomeric form has been added, and determining an antibody against the drug antibody in the sample by a positive immunoassay in i) and a negative immunoassay in ii) and iii).
Public/Granted literature
- US20100304400A1 DISTINGUISHING ASSAY Public/Granted day:2010-12-02
Information query
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