Invention Grant
- Patent Title: Methods for identifying kremen polypeptide binding partners
- Patent Title (中): 识别克雷门多肽结合配偶体的方法
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Application No.: US13066024Application Date: 2011-04-05
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Publication No.: US08227200B2Publication Date: 2012-07-24
- Inventor: Christof Niehrs , Bingyu Mao
- Applicant: Christof Niehrs , Bingyu Mao
- Applicant Address: DE Heidelberg
- Assignee: Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts
- Current Assignee: Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts
- Current Assignee Address: DE Heidelberg
- Agency: Klauber & Jackson LLC
- Priority: EP02008650 20020417
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/566 ; C12Q1/68
Abstract:
The present invention relates to a composition useful for the diagnosis and therapy of diseases associated with aberrant expression of the gene encoding the receptor Kremen 1 and/or Kremen 2 e.g. tumors or diseases of the kidneys, bones and eyes, lipid and glucose metabolism and obesity. The present invention also relates to a pharmaceutical composition containing a compound which is capable of modifying (a) the expression of the gene encoding Kremen 1 and/or Kremen 2 or (b) the activity of the Kremen 1 and/or Kremen 2 receptor.
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