Invention Grant
US08227417B2 HMGN polypeptides as immune enhancers and HMGN antagonists as immune suppressants
有权
HMGN多肽作为免疫增强剂和HMGN拮抗剂作为免疫抑制剂
- Patent Title: HMGN polypeptides as immune enhancers and HMGN antagonists as immune suppressants
- Patent Title (中): HMGN多肽作为免疫增强剂和HMGN拮抗剂作为免疫抑制剂
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Application No.: US12509088Application Date: 2009-07-24
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Publication No.: US08227417B2Publication Date: 2012-07-24
- Inventor: De Yang , Joost J. Oppenheim , Michael Bustin
- Applicant: De Yang , Joost J. Oppenheim , Michael Bustin
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Leydig, Voit & Mayer, Ltd.
- Main IPC: A61K38/19
- IPC: A61K38/19
Abstract:
A method of enhancing an antigen-specific immune response in a host comprising administering to the host an HMGN polypeptide comprising at least one of HMGN1, HMGN3a, HMGN3b, HMGN4, Nsbp1, or a functional fragment thereof, in an amount effective to enhance an antigen-specific immune response; as well as a pharmaceutical composition comprising an HMGN polypeptide comprising at least one of HMGN1, HMGN3a, HMGN3b, HMGN4, Nsbp1, or a functional fragment thereof, and an antigen, or nucleic acids encoding such molecules; and related methods and compositions.
Public/Granted literature
- US20100021488A1 HMGN POLYPEPTIDES AS IMMUNE ENHANCERS AND HMGN ANTAGONISTS AS IMMUNE SUPPRESSANTS Public/Granted day:2010-01-28
Information query
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