Invention Grant
- Patent Title: Oligodeoxynucleotide and its use to induce an immune response
- Patent Title (中): 寡脱氧核苷酸及其用于诱导免疫反应的用途
-
Application No.: US13104918Application Date: 2011-05-10
-
Publication No.: US08227446B2Publication Date: 2012-07-24
- Inventor: Dennis Klinman , Daniela Verthelyi , Ken Ishii , James J. Mond , Mayda Gursel
- Applicant: Dennis Klinman , Daniela Verthelyi , Ken Ishii , James J. Mond , Mayda Gursel
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary of the Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary of the Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/38 ; A61K45/00 ; A61K47/00 ; A61K31/70 ; A61K9/127 ; A01N43/04
Abstract:
D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula: 5′X1X2X3Pu1Py2CpGPu3Py4X4X5X6(W)M(G)N-3′ wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10. Methods of using these oligodeoxynucleotides to induce an immune response are provided.
Public/Granted literature
- US20110212135A1 OLIGODEOXYNUCLEOTIDE AND ITS USE TO INDUCE AN IMMUNE RESPONSE Public/Granted day:2011-09-01
Information query
