Invention Grant
- Patent Title: RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles
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Application No.: US13360894Application Date: 2012-01-30
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Publication No.: US08227447B2Publication Date: 2012-07-24
- Inventor: Marion Jurk , Jorg Vollmer
- Applicant: Marion Jurk , Jorg Vollmer
- Applicant Address: DE Dusseldorf
- Assignee: Coley Pharmaceutical GmbH
- Current Assignee: Coley Pharmaceutical GmbH
- Current Assignee Address: DE Dusseldorf
- Agent Paul M. Misiak
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12Q1/68 ; C07H21/02 ; C12N5/02 ; C12N5/00 ; C07H21/04
Abstract:
Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
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