Invention Grant
US08227450B2 Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation
有权
天冬氨酰蛋白酶抑制剂的赖氨酸类前体药物及其制备方法
- Patent Title: Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation
- Patent Title (中): 天冬氨酰蛋白酶抑制剂的赖氨酸类前体药物及其制备方法
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Application No.: US12086184Application Date: 2006-11-30
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Publication No.: US08227450B2Publication Date: 2012-07-24
- Inventor: Guy Milot , Stephane Branchaud , Brent R. Stranix
- Applicant: Guy Milot , Stephane Branchaud , Brent R. Stranix
- Applicant Address: CA Verdun, QC
- Assignee: Ambrilia Biopharma Inc.
- Current Assignee: Ambrilia Biopharma Inc.
- Current Assignee Address: CA Verdun, QC
- Agency: Clark & Elbing LLP
- International Application: PCT/CA2006/001963 WO 20061130
- International Announcement: WO2007/062526 WO 20070607
- Main IPC: A61K31/661
- IPC: A61K31/661 ; C07F9/09
Abstract:
The present invention provides processes for synthesizing lysine based compounds of the formula; wherein R1 may be, for example, (HO)2P(O)—, (NaO)2P(O)—, wherein X may be, for example, NH2, Y may be H, F, Cl, or Br, and wherein n, X′, Y′, R2, R3, R4, R5 and R6 are as defined herein.
Public/Granted literature
- US20100130765A1 LYSINE-BASED PRODRUGS OF ASPARTYL PROTEASE INHIBITORS AND PROCESSES FOR THEIR PREPARATION Public/Granted day:2010-05-27
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