Invention Grant
- Patent Title: Amorphous body composed of heterocyclic compound, solid dispersion and pharmaceutical preparation each comprising the same, and process for production of the same
- Patent Title (中): 由杂环化合物,固体分散体和各自含有它们的药物制剂组成的无定形体及其制备方法
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Application No.: US12744160Application Date: 2008-11-21
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Publication No.: US08227463B2Publication Date: 2012-07-24
- Inventor: Tadaaki Sugama , Nobuhiro Ishihara , Yoshiharu Tanaka , Masayuki Takahashi , Shinichi Yaguchi , Tetsuo Watanabe
- Applicant: Tadaaki Sugama , Nobuhiro Ishihara , Yoshiharu Tanaka , Masayuki Takahashi , Shinichi Yaguchi , Tetsuo Watanabe
- Applicant Address: JP Tokyo
- Assignee: Zenyaku Kogyo Kabushiki Kaisha
- Current Assignee: Zenyaku Kogyo Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2007-303332 20071122
- International Application: PCT/JP2008/071259 WO 20081121
- International Announcement: WO2009/066775 WO 20090528
- Main IPC: A61K31/535
- IPC: A61K31/535 ; C07D413/14

Abstract:
[Problems] The object is to improve the absorbability of a heterocyclic compound including s-triazine and a pyrimidine derivative in vitro. [Means for Solving Problems] Disclosed is, for example, an amorphous body of a heterocyclic compound as represented by the general formula (I) [wherein each of R's and others is as defined in the description] including s-triazine and a pyrimidine derivative, or a hydrate, a solvate or a pharmaceutically acceptable salt of the heterocyclic compound. Also disclosed is a process for producing the amorphous body. Further disclosed are: a solid dispersion comprising the amorphous body; and a medicinal preparation comprising the solid dispersion.
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