中科微点-全球专利检索

  1. Login
  2. Sign Up
Invention Grant
US08227510B2 Combine use of pterostilbene and quercetin for the production of cancer treatment medicaments 失效
结合使用蝶啶和槲皮素生产癌症治疗药物

Combine use of pterostilbene and quercetin for the production of cancer treatment medicaments
Abstract:
The invention relates to the combined use of pterostilbene and quercetin for the production of cancer treatment medicaments. The in vitro growth of melanoma cells B16-F10 (B16M-F10) is inhibited (56%) by combined exposures of short duration (60 min/day) to PTER (40 μM)+QUER(20 μM) (˜average values of plasma concentrations measured within the first hour following the IV administration of 20 mg of each polyphenol/kg ˜). The combined intravenous administration of PTER+QUER (20 mg/kg× day) to mice inhibits (73%) the metastatic growth of melanoma B16M-F10 in the liver, a common site for metastasis development. The invention demonstrates that the combination of PTER+QUER inhibits the growth of malignant melanoma metastasis and prolongs the survival of the carrier host.
Abstract(Chinese):

本发明涉及莠去津和槲皮素联合应用于癌症治疗药物的生产。 黑色素瘤细胞B16-F10（B16M-F10）的体外生长通过短时间（60分钟/天）与PTER（40μM）+ QUER（20μM）的联合暴露（〜 IV给药后的第一个小时内测量的血浆浓度为20mg每种多酚/ kg〜）。 将PTER + QUER（20 mg / kg×day）联合静脉注射给小鼠抑制（73％）肝脏黑素瘤B16M-F10的转移生长，这是转移发生的常见部位。 本发明表明，PTER + QUER的组合抑制恶性黑素瘤转移的生长并延长载体宿主的存活。

Public/Granted literature
Information query
Espacenet
Patent Agency Ranking
0/0