Invention Grant
US08227604B2 Hybrid 2-aminotetralin and aryl-substituted piperazine compounds and their use in altering CNS activity
有权
杂合2-氨基四氢萘酮和芳基取代的哌嗪化合物及其在改变CNS活性中的用途
- Patent Title: Hybrid 2-aminotetralin and aryl-substituted piperazine compounds and their use in altering CNS activity
- Patent Title (中): 杂合2-氨基四氢萘酮和芳基取代的哌嗪化合物及其在改变CNS活性中的用途
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Application No.: US12770079Application Date: 2010-04-29
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Publication No.: US08227604B2Publication Date: 2012-07-24
- Inventor: Aloke K. Dutta
- Applicant: Aloke K. Dutta
- Applicant Address: US MI Detroit
- Assignee: Wayne State University
- Current Assignee: Wayne State University
- Current Assignee Address: US MI Detroit
- Agency: Brooks Kushman P.C.
- Main IPC: C07D403/00
- IPC: C07D403/00 ; C07D295/00
Abstract:
Hybrid compounds containing an aminotetralin moiety or a heterocyclic and/or open chain analog thereof linked through an alkylene group to an aryl ring system-substituted piperidiene moiety exhibit high levels of CNS activity, in some cases exhibiting especially high relative binding efficiencies between D3 and D2 dopaminergic receptor subtypes.
Public/Granted literature
- US20100210663A1 Hybrid 2-Aminotetralin and Aryl-Substituted Piperazine Compounds and their Use in Altering CNS Activity Public/Granted day:2010-08-19
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