Invention Grant
US08227611B2 Process for the preparation of hexahydroisoquinolines from 1,2,3,4-tetrahydroisoquinolines
有权
从1,2,3,4-四氢异喹啉制备六氢异喹啉的方法
- Patent Title: Process for the preparation of hexahydroisoquinolines from 1,2,3,4-tetrahydroisoquinolines
- Patent Title (中): 从1,2,3,4-四氢异喹啉制备六氢异喹啉的方法
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Application No.: US12482036Application Date: 2009-06-10
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Publication No.: US08227611B2Publication Date: 2012-07-24
- Inventor: Gary L. Cantrell , Dan P. Magparangalan , Frank W. Moser , Jian Bao , Christopher W. Grote , Peter X. Wang
- Applicant: Gary L. Cantrell , Dan P. Magparangalan , Frank W. Moser , Jian Bao , Christopher W. Grote , Peter X. Wang
- Applicant Address: US MO Hazelwood
- Assignee: Mallinckrodt LLC
- Current Assignee: Mallinckrodt LLC
- Current Assignee Address: US MO Hazelwood
- Main IPC: C07D217/02
- IPC: C07D217/02
Abstract:
The present invention is directed to processes for the synthesis of morphinans. In particular, a process for the asymmetric reduction of an imine moiety in a 3,4-dihydroisoquinoline to produce a tetrahydroisoquinoline, followed by a Birch reduction to produce a hexahydroisoquinoline. In various embodiments, the 3,4-dihydroisoquinoline contains a phenol moiety protected with a labile protecting group. In other embodiments, the imine reduction reaction mixture contains silver tetrafluoroborate.
Public/Granted literature
- US20090247756A1 Process for the Preparation of Hexahydroisoquinolines from 1,2,3,4-Tetrahydroisoquinolines Public/Granted day:2009-10-01
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