Invention Grant
US08227625B2 4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands
有权
4,5,6,7-四氢苯并[b]噻吩衍生物及其作为σ受体配体的用途
![4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands](/docs/US/2012-07-24/US08227625B2/abs.jpg.600x600.jpg)
- Patent Title: 4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands
- Patent Title (中): 4,5,6,7-四氢苯并[b]噻吩衍生物及其作为σ受体配体的用途
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Application No.: US12281317Application Date: 2007-03-02
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Publication No.: US08227625B2Publication Date: 2012-07-24
- Inventor: Jordi Corbera-Arjona , Daniel Martinez-Olmo , David Vano-Domenech
- Applicant: Jordi Corbera-Arjona , Daniel Martinez-Olmo , David Vano-Domenech
- Applicant Address: ES Barcelona
- Assignee: Laboratorios del Dr. Esteve, S.A.
- Current Assignee: Laboratorios del Dr. Esteve, S.A.
- Current Assignee Address: ES Barcelona
- Agency: Heslin Rothenberg Farley & Mesiti P.C.
- Agent Andrew K. Gonsalves
- Priority: EP06004286 20060302
- International Application: PCT/EP2007/001824 WO 20070302
- International Announcement: WO2007/098961 WO 20070907
- Main IPC: C07D333/00
- IPC: C07D333/00
![4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands](/abs-image/US/2012/07/24/US08227625B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to compounds having pharmacological activity towards the sigma (σ) receptor, and more particularly to some 4,5,6,7 tetrahydrobenzo[b]thiophene derivatives, wherein n is selected from 0, 1, 2, 3 or 4; m is selected from 0, 1 or 2; the dotted line represents either a single or a double bond; to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and prophylaxis, in particular for the treatment of psychosis.
Public/Granted literature
- US20090221572A1 4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE DERIVATIVES AND THEIR USE AS SIGMA RECEPTOR LIGANDS Public/Granted day:2009-09-03
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