Invention Grant
US08227639B2 N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
有权
N-羟基磺酰胺衍生物作为新的生理有用的硝酰基供体
- Patent Title: N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
- Patent Title (中): N-羟基磺酰胺衍生物作为新的生理有用的硝酰基供体
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Application No.: US12239705Application Date: 2008-09-26
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Publication No.: US08227639B2Publication Date: 2012-07-24
- Inventor: John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
- Applicant: John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
- Applicant Address: US MD Hunt Valley US MD Baltimore
- Assignee: Cardioxyl Pharmaceuticals,The Johns Hopkins University
- Current Assignee: Cardioxyl Pharmaceuticals,The Johns Hopkins University
- Current Assignee Address: US MD Hunt Valley US MD Baltimore
- Agency: Arnold & Porter LLP
- Agent Suet M. Chong
- Main IPC: C07C303/00
- IPC: C07C303/00
Abstract:
The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.
Public/Granted literature
- US20090163487A1 N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS Public/Granted day:2009-06-25
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