A workflow method for temporal nodule review by registering a reference image R with a floating image F, convolving the reference image R and the floating image with the same window function Hw to generate Rw and Fw, generating a subtraction image by performing subtraction Rw−Fw (g(r)) wherein r represents a voxel (x, y, z) in reference image R, applying a pattern detector to said subtraction image to detect corresponding nodules in reference image R and floating image F and displaying corresponding nodules.