The present invention is directed towards systems and methods for providing dynamic proximity load balancing via a multi-core intermediary device. An intermediary device providing global server load balancing (GSLB) identifies a local domain name service (LDNS) entries database and assigns each LDNS entry in the LDNS entries database to one of the plurality of packet processing engine base on a source internet protocol (IP) address of each LDNS entry. The first packet processing engine on the appliance receives a LDNS request for an IP address, determines that the LDNS entry for the IP address is assigned to a second packet processing engine of the plurality of packet processing engines, transmits a request to the second packet processing engine for the LDNS entry for the IP address, and determines a response to the LDNS request based on the LDNS entry for the IP address received from the second packet processing engine.