Invention Grant
- Patent Title: Heterocyclic compounds and methods of use
- Patent Title (中): 杂环化合物和使用方法
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Application No.: US12641141Application Date: 2009-12-17
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Publication No.: US08232273B2Publication Date: 2012-07-31
- Inventor: Jonathan Bayldon Baell , Chinh Thien Bui , Peter Colman , Peter Czabotar , Danette A. Dudley , Wayne J. Fairbrother , John A. Flygare , Guillaume Laurent Lessene , Chudi Ndubaku , George Nikolakopoulos , Brad Edmund Sleebs , Brian John Smith , Keith Geoffrey Watson , Steven W. Elmore , Lisa A. Hasvold , Andrew M. Petros , Andrew J. Souers , Zhi-Fu Tao , Le Wang , Xilu Wang , Kurt Deshayes
- Applicant: Jonathan Bayldon Baell , Chinh Thien Bui , Peter Colman , Peter Czabotar , Danette A. Dudley , Wayne J. Fairbrother , John A. Flygare , Guillaume Laurent Lessene , Chudi Ndubaku , George Nikolakopoulos , Brad Edmund Sleebs , Brian John Smith , Keith Geoffrey Watson , Steven W. Elmore , Lisa A. Hasvold , Andrew M. Petros , Andrew J. Souers , Zhi-Fu Tao , Le Wang , Xilu Wang , Kurt Deshayes
- Applicant Address: US CA South San Francisco US IL Abbott Park AU Victoria
- Assignee: Genentech, Inc.,Abbott Laboratories,The Walter and Eliza Hall Institute of Medical Research
- Current Assignee: Genentech, Inc.,Abbott Laboratories,The Walter and Eliza Hall Institute of Medical Research
- Current Assignee Address: US CA South San Francisco US IL Abbott Park AU Victoria
- Agency: Jones Day
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; C07D413/14
Abstract:
In one aspect, the present invention provides for a compound of Formula I in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.
Public/Granted literature
- US20100210622A1 HETEROCYCLIC COMPOUNDS AND METHODS OF USE Public/Granted day:2010-08-19
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