中科微点-全球专利检索

  1. Login
  2. Sign Up
Invention Grant
US08232424B2 Method for the use of [11C]carbon monoxide in labeling synthesis of 11C-labelled acids by photo-induced free radical carbonylation under mild conditions using sulfoxides 失效
使用[11C]一氧化碳在轻度条件下使用亚砜的光诱导自由基羰基化标记合成11C标记酸的方法

  • Patent Title: Method for the use of [11C]carbon monoxide in labeling synthesis of 11C-labelled acids by photo-induced free radical carbonylation under mild conditions using sulfoxides
  • Patent Title (中): 使用[11C]一氧化碳在轻度条件下使用亚砜的光诱导自由基羰基化标记合成11C标记酸的方法
  • Application No.: US11917232
    Application Date: 2006-06-14
  • Publication No.: US08232424B2
    Publication Date: 2012-07-31
  • Inventor: Bengt Langstrom , Oleksiy Itsenko
  • Applicant: Bengt Langstrom , Oleksiy Itsenko
  • Applicant Address: GB Little Chalfont
  • Assignee: GE Healthcare Limited
  • Current Assignee: GE Healthcare Limited
  • Current Assignee Address: GB Little Chalfont
  • International Application: PCT/IB2006/001592 WO 20060614
  • International Announcement: WO2006/134474 WO 20061221
  • Main IPC: C07C51/00
  • IPC: C07C51/00 ;  G21C1/00 ;  B01J19/08 ;  A61L9/00
Method for the use of [11C]carbon monoxide in labeling synthesis of 11C-labelled acids by photo-induced free radical carbonylation under mild conditions using sulfoxides
Abstract:
Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with sulfoxides and triethylamine are provided. The resultant carbon-isotope labeled acids, and pharmaceutical acceptable salts and solvates are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits and method for PET studies are also provided.
Abstract(Chinese):

提供了使用具有亚砜和三乙胺的烷基/芳基碘化物用碳同位素标记的一氧化碳进行光引发羰基化的方法和试剂。 所得的碳同位素标记的酸和药学上可接受的盐和溶剂合物可用作放射性药物，特别是用于正电子发射断层扫描（PET）。 还提供了关于PET研究的试剂盒和方法。

Public/Granted literature
Information query
Espacenet
Patent Agency Ranking
0/0