Invention Grant
US08234077B2 Method of selecting genes from gene expression data based on synergistic interactions among the genes
有权
基于基因之间的协同相互作用从基因表达数据中选择基因的方法
- Patent Title: Method of selecting genes from gene expression data based on synergistic interactions among the genes
- Patent Title (中): 基于基因之间的协同相互作用从基因表达数据中选择基因的方法
-
Application No.: US12307694Application Date: 2007-05-10
-
Publication No.: US08234077B2Publication Date: 2012-07-31
- Inventor: Dimitris Anastassiou , Vinay Varadan
- Applicant: Dimitris Anastassiou , Vinay Varadan
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agency: Baker Botts L.L.P.
- International Application: PCT/US2007/068666 WO 20070510
- International Announcement: WO2007/134167 WO 20071122
- Main IPC: G01N33/48
- IPC: G01N33/48 ; C12Q1/68 ; G06F7/60 ; G06G7/58
Abstract:
A method is provided for selecting two or more genes from gene expression data. In the method, gene expression data for a plurality of genes is provided, where the gene expression data include expression levels for each of the plurality of genes. The gene expression data is discretized. Based on the discretized gene expression data, the synergy among the plurality of genes with respect to a phenotype, for example, presence or absence of a disease in a tissue, is evaluated. Two or more genes whose synergy exceeds a predetermined threshold are selected. A system implementing the method is also provided.
Public/Granted literature
- US20090299643A1 Computational Analysis Of The Synergy Among Multiple Interacting Factors Public/Granted day:2009-12-03
Information query
