Invention Grant
US08236308B2 Composition comprising cross-species-specific antibodies and uses thereof
有权
包含交叉物种特异性抗体的组合物及其用途
- Patent Title: Composition comprising cross-species-specific antibodies and uses thereof
- Patent Title (中): 包含交叉物种特异性抗体的组合物及其用途
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Application No.: US12083351Application Date: 2006-10-10
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Publication No.: US08236308B2Publication Date: 2012-08-07
- Inventor: Roman Kischel , Tobias Raum , Bernd Schlereth , Doris Rau , Ronny Cierpka , Peter Kufer
- Applicant: Roman Kischel , Tobias Raum , Bernd Schlereth , Doris Rau , Ronny Cierpka , Peter Kufer
- Applicant Address: DE Munich
- Assignee: Micromet AG
- Current Assignee: Micromet AG
- Current Assignee Address: DE Munich
- Agency: Foley & Lardner LLP
- International Application: PCT/EP2006/009782 WO 20061010
- International Announcement: WO2007/042261 WO 20070419
- Main IPC: A61K39/395
- IPC: A61K39/395
Abstract:
The present invention relates to uses of bispecific antibodies exhibiting cross-species specificity for evaluating the in vivo safety and/or activity and/or pharmacokinetic profile of the same in non-human species and humans. The present invention moreover relates to methods for evaluating the in vivo safety and/or activity and/or pharmacokinetic profile of said bispecific anti-bodies exhibiting cross-species specificity. The present invention also relates to methods of measuring the biological activity and/or efficacy of such bispecific antibodies exhibiting cross-species specificity. In addition, the present invention relates to pharmaceutical compositions comprising bispecific single chain antibodies exhibiting cross-species specificity and to methods for the preparation of pharmaceutical compositions comprising said bispecific single chain antibodies exhibiting cross-species specificity for the treatment of diseases.
Public/Granted literature
- US20090252683A1 Composition Comprising Cross-Species-Sepecific Antibodies and uses Thereof Public/Granted day:2009-10-08
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