Invention Grant
- Patent Title: Screening method for compounds that reduce ER stress
- Patent Title (中): 减少ER应激的化合物的筛选方法
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Application No.: US12663241Application Date: 2008-06-06
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Publication No.: US08236490B2Publication Date: 2012-08-07
- Inventor: Christophe Francois Aime Roca , José Manuel Bernardo Sousa , Marta Isabel Heitor Cerejo , Alexandra Maria Barros Dos Santos , Cátia Santana Reverendo Rodrigues , Ricardo Filipe Antunes Pinheiro , Patricia Ramalhete Mendes da Silva Calado , Sukalyan Chatterjee , Helena Margarida Moreira de Oliveira Vieira
- Applicant: Christophe Francois Aime Roca , José Manuel Bernardo Sousa , Marta Isabel Heitor Cerejo , Alexandra Maria Barros Dos Santos , Cátia Santana Reverendo Rodrigues , Ricardo Filipe Antunes Pinheiro , Patricia Ramalhete Mendes da Silva Calado , Sukalyan Chatterjee , Helena Margarida Moreira de Oliveira Vieira
- Applicant Address: PT Lisbon
- Assignee: EM Biotecnologia S.A.
- Current Assignee: EM Biotecnologia S.A.
- Current Assignee Address: PT Lisbon
- Agency: Gavrilovich Dodd & Lindsey LLP
- Agent Joseph R. Baker, Jr.
- Priority: GB0710976.2 20070607
- International Application: PCT/PT2008/000025 WO 20080606
- International Announcement: WO2008/150186 WO 20081211
- Main IPC: C12Q1/00
- IPC: C12Q1/00 ; C12N1/00 ; C12N15/741
Abstract:
The present invention relates to a cell comprising an Endoplasmic Reticulum (ER) stress element operably linked to a reporter element and an exogenous gene encoding a protein that induces ER stress. Methods of screening using the modified cell, constructs used in the modified cell, the candidate agents identified by the screen and uses thereof are also part of the invention.
Public/Granted literature
- US20100215641A1 SCREENING METHOD FOR COMPOUNDS THAT REDUCE ER STRESS Public/Granted day:2010-08-26
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