Invention Grant
- Patent Title: Method for methanol independent induction from methanol inducible promoters in Pichia
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Application No.: US13396925Application Date: 2012-02-15
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Publication No.: US08236528B2Publication Date: 2012-08-07
- Inventor: Shinobu Takagi , Noriko Tsutsumi , Yuji Terui , XiangYu Kong
- Applicant: Shinobu Takagi , Noriko Tsutsumi , Yuji Terui , XiangYu Kong
- Applicant Address: DK Bagsvaerd
- Assignee: Novozymes A/S
- Current Assignee: Novozymes A/S
- Current Assignee Address: DK Bagsvaerd
- Agent Michael W. Krenicky
- Priority: DK200700122 20070126
- Main IPC: C12P21/06
- IPC: C12P21/06
Abstract:
A method for producing a polypeptide in a methylotrophic yeast host cell is described, where expression of the polypeptide is controlled by a methanol inducible promoter, including: i) expression of a positive regulator from a non-native promoter, the positive regulator activating transcription from the methanol inducible promoter, and ii) no addition of methanol.
Public/Granted literature
- US20120142053A1 METHOD FOR METHANOL INDEPENDENT INDUCTION FROM METHANOL INDUCIBLE PROMOTERS IN PICHIA Public/Granted day:2012-06-07
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